biochemistry of copper biochemistry of the elements

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Biochemistry Of Copper

Author : Maria C. Linder
ISBN : 9781475794328
Genre : Science
File Size : 23. 8 MB
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Copper has long been known as essential to living systems, in part through its fundamental role in electron transport and respiration. Over the years into the present, its involvement in an ever increasing number of processes in all kinds of organisms has become apparent, and new and exciting vistas of its roles in such areas as the central nervous system, and in humoral functions, are appearing on the horizon. Although the biochemistry of this element has not been studied nearly as much as that of many others, a for midable amount of work has been carried out. It has thus been a challenge to produce a summary of what has been found that provides both breadth and depth. My goal has been to try to be as comprehensive as possible, within some limitations. I have tried to provide basic information and basic data that should continue to be useful for a long time. The goal has also been to interpret where we currently stand in our knowledge of the structure, function, regulation, and metabolism of Cu-dependent processes and sub stances, especially proteins. Thus, I have tried to make this a source book for historic as well as current information on all aspects of copper bio chemistry, and a summary of our current knowledge of copper-dependent proteins and processes. Most of the research on copper has been carried out on vertebrates, especially mammals. This has played a role in the organization of the book.

Biochemistry Of The Essential Ultratrace Elements

Author : Earl Frieden
ISBN : 9781468447750
Genre : Science
File Size : 42. 2 MB
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The remarkable development of molecular biology has had its counterpart in an impressive growth of a segment of biology that might be described as atomic biology. The past several decades have witnessed an explosive growth in our knowledge of the many elements that are essential for life and maintenance of plants and animals. These essential elements include the bulk elements (hydro gen, carbon, nitrogen, oxygen, and sulfur), the macrominerals (sodium, potas sium, calcium, magnesium, chloride, and phosphorus), and the trace elements. This last group includes the ultra trace elements and iron, zinc, and copper. Only the ultratrace elements are featured in this book. Iron has attracted so much research that two volumes are devoted to this metal-The Biochemistry of Non-Heme Iron by A. Bezkoravainy, Plenum Press, 1980, and The Biochemistry of Heme Iron (in preparation). Copper and zinc are also represented by a separate volume in this series. The present volume begins with a discussion of essentiality as applied to the elements and a survey of the entire spectrum of possible required elements.

Trace Elements In Human And Animal Nutrition

Author : E Underwood
ISBN : 9780323162180
Genre : Science
File Size : 68. 27 MB
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Trace Elements in Human and Animal Nutrition, Fourth Edition, explores the physiological roles of trace elements in human and animal nutrition. It looks at the needs, tolerances, and interactions of trace elements with each other and with other nutrients and compounds, and it explores how deficient, toxic, or imbalanced intakes of such elements lead to biochemical and pathological changes. It also describes ways of diagnosing and addressing such aberrant intakes of trace elements, along with their principal sources. Organized into 20 chapters, this volume begins with an overview of the nature of trace elements and their mode of action, including iron, copper, molybdenum, cobalt, nickel, manganese, zinc, cadmium, chromium, iodine, selenium, fluorine, mercury, vanadium, silicon, lead, and arsenic. It then discusses the presence of these elements in animal tissues and fluids, along with their metabolism, functions, and toxicity. It also considers other elements, such as aluminum, antimony, barium, boron, bromine, germanium, lithium, rubidium, silver, strontium, tin, titanium, and zirconium. The book concludes with an analysis of the interrelationships among soil, plants, and animals. This book should be a valuable resource for students and chemists.

General Principles Of Biochemistry Of The Elements

Author : Ei-Ichiro Ochiai
ISBN : 9781468453713
Genre : Science
File Size : 52. 66 MB
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The present book might be regarded as a sequel to my previous work, Bioinorganic Chemistry: An Introduction (Allyn and Bacon, 1977). The latter is essentially a collection of chemical and physical data pertinent to an understanding of the biological functions of the various elements and the proteins dependent on them. The ten years since its publication have seen an enormous increase in research activity in this area, hence of research papers. A number of monographs and review series on specific topics have also appeared, including the volumes in the series of which the present volume is a part. Nevertheless, a gap has developed between the flood of information available at a detailed level (papers and reviews) and a general description of the underlying principles of biofunctions of the elements as presently conceived. It is hoped that this book will help bridge this gap and at the same time provide an overview of the entire Biochemistry of the Elements series. Specifically, the work attempts to focus on "why" questions, especially, "Why has an element been chosen by organisms for a specific biofunction?" and "Why does an element behave the way it does in biological systems?" It therefore complements my 1977 book and, together with Laboratory Introduction to Bio-Inorganic Chemistry (E. -I. Ochiai and D. R. Williams, Macmillan, 1979), completes a trilogy on the topic of bioinorganic chemistry. This book consists of five parts. Two chapters constitute Part I.

Nutritional Elements And Clinical Biochemistry

Author : Marge A. Brewster
ISBN : 9781461331681
Genre : Juvenile Nonfiction
File Size : 86. 44 MB
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The important role that the nutritional status exerts in determining the course of life from birth to death in the human being and especially its impact in disease states is only par tially appreciated at this time. Nutritional deficiencies are usually considered to be major problems only in under-privileged or developing populations, except for those occurring in specific diseases. This attitude is incorrect as indicated by reports of Bestrian et al (1974, 1976) and Merritt and Suskin (1979) and others who found evidence of nutritional depletion in as much as 50% of the patients in varied groups of hospitalized patients in the United States. Other studies, some of which are included in this book, emphasized the existence of deficiencies of certain specific nutrients. Despite evidence of nutritional deficiencies occurring more frequently than previously appreciated, there is no well established protocol of laboratory studies that the clinical chemist or scientist should provide to help the physician detect lack of essential nutrients before extensive and possibly irreparable damage has occurred to the individual patient. Considerable research data are needed to determine the best biologic material (i.e., erythrocytes, leucocytes, plasma, serum, urine, cerebrospinal fluid, lymph) for analysis to determine accurately at an early stage metabolic deficiencies due to a specific nutritional element. Improved techniques for analysis of key metabolites and nutrients are available in the research labora tory and many of them can be adapted to the clinical laboratory.

Plants And The Chemical Elements

Author : Margaret E. Farago
ISBN : 9783527615902
Genre : Science
File Size : 23. 15 MB
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How do plants react to elements in the soil? A vital question, particulary in today's world of increasing environmental contamination... The answer can be found in this book. It has an extraordinarily broad basis, compiling up-to-date information from numerous specialist disciplines. Key articles are devoted to - Soil Chemistry and Bioavailability - Metal-tolerant Plants - Metalloenzymes - Toxic Effects of Metals - Radionuclides Moreover emphasis is placed on environmental aspects, with detailed considerations of plants that hyperaccumulate heavy metals and plants that are indicators for pollution. A discussion of experimental techniques rounds off the book. They include sampling, sample preparation, analytical methods and aspects of quality assurance. All in all a valuable forum for the exchange of current thinking across a broad spectrum of disciplines.

Trace Elements In Man And Animals 9

Author : Peter Wilhelm Fritz Fischer
ISBN : 0660164043
Genre : Trace elements Physiological effect Congresses
File Size : 59. 48 MB
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Presents papers from an international meeting of specialists from a variety of disciplines sharing an interest in trace elements. The papers are organized into broad categories covering such topics as trace element interactions in the food supply and nutrition; trace elements and genetic regulation; trace elements in pregnancy and lactation; assessment of trace element status; kinetic modelling; trace elements in the environment and food supply; trace elements, brain function, and behaviour; membrane function and cell signalling; analytical, experimental, and isotopic techniques; ethics of trace element research; defining trace element requirements of infants; trace element intervention studies; trace elements and animal production, free-radical mediated disease, and food and nutrition policy; analytical quality control; infection and immune function; trace element binding proteins; trace elements in growth and metabolism; mechanisms of trace element toxicity; and metabolic and physiological consequences of trace element deficiencies.

Transition Metals In Biochemistry

Author : Arthur Brill
ISBN : 9783642811487
Genre : Science
File Size : 62. 25 MB
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Transition metal ions in biological systems are of interest in biology, biochemistry, chemistry, medicine, and physics. Scien tists with rather different viewpoints, employing many methods, have contributed to this area. A concise review of the current state of the field will, to some extent, reflect the special knowledge of the person writing it - in this case application of physical methods to the investigation of metal coordination. x ray diffraction is one of the most important of these methods, but a useful treatment of X-ray structure analysis would be com parable in size with and beyond the scope of the monograph. Many results of X-ray diffraction studies are, of course, presented. Electron paramagnetic resonance spectroscopy has played a major part in the rapid advance in knowledge of the electronic struc tures of transition metal ions in biological systems. More gener ally, measurements involving light, microwaves, and magnetic fields are capable of producing much new information, and the required instrumentation is available at most research institu tions. Therefore light absorption and paramagnetic resonance are treated in depth. The principles described in the latter discus sions are broadly applicable, for example to the promising tech niques of X-ray spectroscopy (utilizing synchrotron radiation) and lanthanide-perturbed, very high-resolution nuclear magnetic resonance spectroscopy.

Clinical Biochemistry

Author : William J. Marshall
ISBN : 9780702054785
Genre : Medical
File Size : 22. 90 MB
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Essential reading for candidates for the MRCPath examination and similar postgraduate examinations in clinical biochemistry. The book gives an overview of the acquisition of data, as well as concentrating on clinical aspects of the subject, giving detailed coverage of all conditions where clinical biochemistry is used in diagnosis and management. In common with other diagnostic specialties clinical biochemistry now uses an increasing number of techniques involving the 'new biology': these are covered in this book. It is also increasingly common for medically qualified clinical biochemists to become involved in the clinical management of patients (eg nutritional support) and material on this will be included. Significant changes to content to reflect changes in how clinical chemistry services are organised and to reflect the advent of metabolic medicine as a recognised specialty. Chapter on Clinical biochemistry of nutrition to include new information on regulation of appetite and the clinical management of obesity. New chapter to bring together information on inborn errors of metabolism affecting adults. New chapter on clinical biochemistry of cardiovascular disease. The diabetes chapter has been split into two separate chapters to allow more detailed description of the practical clinical management of the disease.

Clinical Biochemistry Of Domestic Animals

Author : Jiro Jerry Kaneko
ISBN : 0080568823
Genre : Technology & Engineering
File Size : 28. 88 MB
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The 6th edition of a well-known and much used standard text in the field. This book covers all aspects of the biochemical abnormalities caused by various diseases and how they relate to the biochemical changes in the blood, urine, cerebrospinal fluid, joint fluids, other body fluids and in cells. The purpose is to provide the fundamental bases for understanding the biochemical changes that occur in disease processes and in turn to provide the rationale for applying this understanding to the diagnosis of the disease process. A substantial appendix is provided so that the user can quickly identify the reference ranges for a large number of animal species. * An appendix is provided in the book so that the user can quickly identify the reference ranges for a large number of animal species * Explains what biochemical changes occur in disease processes and provides the rationale for applying this understanding to the diagnosis of the disease process

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